Tác giả: Phòng Thông Tin Truyền Thông (Thông Tin Truyền Thông Phòng)

Abstract Introduction:  Shared neoantigens derived from recurrent mutations represent promising targets for off-the-shelf (OTS) cancer immunotherapies; however, their clinical utility is often constrained by population-specific HLA diversity and variable immunogenicity. There remains a need for population-tailored neoantigen panels with broad HLA coverage and functional validation. Methods:  We developed a colorectal cancer (CRC)–specific OTS neoantigen panel...

Abstract Counterfactual explanations (CE) can make face classifiers more transparent, yet existing methods implicitly target a single attribute at a time, yield unnatural imagery, overly broad or off-target edits, and weak interpretability. We introduce a unified framework that (i) constrains edits with FacePart-based segmentation masks, (ii) performs localized blended latent diffusion on Stable Diffusion 2.1,...

Abstract Acute kidney injury (AKI) involves oxidative stress, inflammation, and metabolic toxin accumulation, leading to renal dysfunction and systemic metabolic disorders. Current treatments provide limited efficacy and fail to address the interplay between renal and intestinal pathologies. Here, we present a noninvasive dual-action oral platform that integrates systemic and gut-targeted therapeutic effects to restore homeostasis...