Abstract The rapid development of the textile industry has led to the discharge of large amounts of dyes into aquatic environments, such as rivers and lakes. Long-term exposure to these substances causes many adverse health effects. Therefore, compact, highly sensitive sensors that enable rapid, on-site assessment of water quality have received significant attention. High-performance SERS substrates were successfully fabricated by optimizing and controlling the thickness of the shell of core–shell Au@Ag NPs by using both experimental and FDTD calculations. Results on the individual and simultaneous detection of dyes demonstrate the potential of Au@Ag NPs as substrates for environmental applications, where...

Abstract Introduction:  Shared neoantigens derived from recurrent mutations represent promising targets for off-the-shelf (OTS) cancer immunotherapies; however, their clinical utility is often constrained by population-specific HLA diversity and variable immunogenicity. There remains a need for population-tailored neoantigen panels with broad HLA coverage and functional validation. Methods:  We developed a colorectal cancer (CRC)–specific OTS neoantigen panel by integrating TCGA mutation data with HLA class I binding predictions across 68 alleles (18 HLA-A, 34 HLA-B, and 16 HLA-C), covering both Asian and Caucasian populations. Candidate neoantigens were evaluated in a Vietnamese CRC cohort (n = 67) based on mutation and HLA matching....

Abstract Shrimp farming wastewater is a high-salinity and nutrient-rich effluent that contributes to eutrophication, disrupts aquatic ecosystems, and degrades natural habitats. In this study, a microalgae-based membrane bioreactor (A-MBR) integrating Chlorella sorokiniana with activated sludge was developed and evaluated for nutrient removal from synthetic shrimp farming wastewater under saline conditions. The performance of the A-MBR was systematically compared with that of a conventional membrane bioreactor (C-MBR). The A-MBR achieved superior removal efficiencies of 83.7 ± 7.7% for ammonium (NH4+-N), 57.8 ± 27.1% for total nitrogen (TN), and 41.5 ± 10.3% for total phosphorus (TP), outperforming the C-MBR and indicating improved treatment performance and bioreactor stability under salinity stress....

Abstract Graphitic carbon nitride (g-C3N4) has been widely used as a material for hydrogen evolution reaction (HER) due to its visible-light activity, low cost, and non-toxicity. However, a rapid recombination of photogenerated electron-hole pairs, poor electrical conductivity, and a low specific surface area of g-C3N4 have hindered its practical performance. Melem/g-C3N4 (abbreviate: MCN) is a newer structure than g-C3N4 and has better light absorption as well as lower electron/hole recombination than pristine g-C3N4. Herein, we report on loading different amounts of nickel nanoparticles (Ni NPs) onto supramolecule-based MCN using chemical reduction. The results showed that incorporating Ni NPs on the surface of MCN...