Thẻ: SDG4-Giáo dục có chất lượng

Abstract Many molecular systems, such as intrinsically disordered proteins and flexible multi-domain complexes, are highly dynamic and often inaccessible to conventional X-ray crystallography or cryo-EM due to their conformational heterogeneity and flexibility. As a result, resolving their atomic-level dynamics remains a significant challenge. In this study, we present SimHS-AFMfit-MD, an integrative framework that combines high-speed...

Abstract Introduction:  Shared neoantigens derived from recurrent mutations represent promising targets for off-the-shelf (OTS) cancer immunotherapies; however, their clinical utility is often constrained by population-specific HLA diversity and variable immunogenicity. There remains a need for population-tailored neoantigen panels with broad HLA coverage and functional validation. Methods:  We developed a colorectal cancer (CRC)–specific OTS neoantigen panel...

Abstract Shrimp farming wastewater is a high-salinity and nutrient-rich effluent that contributes to eutrophication, disrupts aquatic ecosystems, and degrades natural habitats. In this study, a microalgae-based membrane bioreactor (A-MBR) integrating Chlorella sorokiniana with activated sludge was developed and evaluated for nutrient removal from synthetic shrimp farming wastewater under saline conditions. The performance of the A-MBR was systematically...